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Sufferers treated with flumazenil need to be monitored for re-sedation, respiratory depression, together with other residual benzodiazepine consequences for an appropriate period soon after treatment method. The prescriber ought to pay attention to a danger of seizure in association with flumazenil remedy, significantly in prolonged-term benzodiazepine users As well as in cyclic antidepressant overdose. The whole flumazenil offer insert ought to be consulted previous to use.
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When tapering, minimize dosage by no more than 0.5 mg every single 3 days. Some individuals may possibly involve a fair slower dosage reduction. See the complete prescribing facts with the recommended dosage in geriatric patients, patients with hepatic impairment, and with use with ritonavir.